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Her big screen breakthrough came in Honey (2003). She soon established herself as a Hollywood actress, and has starred in numerous box office hits throughout her career, including Fantastic Four (2005), Fantastic Four: Rise of the Silver Surfer (2007), Good Luck Chuck (2007), The Eye (2008), Valentine's Day (2010), Little Fockers (2010), and Mechanic: Resurrection (2016). She is a frequent collaborator of director Robert Rodriguez, having starred in Sin City (2005), Machete (2010), Spy Kids: All the Time in the World (2011), Machete Kills (2013), and Sin City: A Dame to Kill For (2014). Since 2019, Alba stars in the Spectrum action crime series L. A. 's Finest.

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